Nevşehir Hacı Bektaş Veli University Course Catalogue
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| Year/Semester of Study | 1 / Fall Semester | ||||
| Level of Course | 2nd Cycle Degree Programme | ||||
| Type of Course | Optional | ||||
| Department | CHEMISTRY (MASTER'S DEGREE) | ||||
| Pre-requisities and Co-requisites | None | ||||
| Mode of Delivery | Face to Face | ||||
| Teaching Period | 14 Weeks | ||||
| Name of Lecturer | BAHAR TUBA FINDIK (btfindik@nevsehir.edu.tr) | ||||
| Name of Lecturer(s) | |||||
| Language of Instruction | Turkish | ||||
| Work Placement(s) | None | ||||
| Objectives of the Course | |||||
| Teaching the basic concepts related to blood buffers; enzymes as biological catalyst, enzyme kinetics, reaction order, methods of plotting enzyme kinetics data, enzyme inhibition | |||||
| Learning Outcomes | PO | MME | |
| The students who succeeded in this course: | |||
| LO-1 | can explain a reaction rate in terms of a change in concentration divided by a change in time (at constant volume) and rate law; can explain the activation energy of chemical reactions; can define the mechanisms of enzyme activity; explain the properties of enzyme-catalysed reactions; and understand enzyme kinetics. |
PO-1 Upon successful completion of this programme, graduate students will: Have advance knowledge and skills in the area of specialized.
PO-2 Do enough practical and theoretical advance studies. PO-3 Evaluate the scientific data obtained from advance studies and present scientific results. PO-5 Follow the literature in the area of specialized. |
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| LO-2 | can explain the theory and practice of elucidating biomolecular mechanisms, including enzyme action, protein folding, protein-nucleic acid interactions and molecular motors. |
PO-1 Upon successful completion of this programme, graduate students will: Have advance knowledge and skills in the area of specialized.
PO-3 Evaluate the scientific data obtained from advance studies and present scientific results. |
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| PO: Programme Outcomes MME:Method of measurement & Evaluation |
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| Course Contents | ||
| Acid-base chemistry: aqueous solutions, equilibrium constants, acids and bases, laboratory buffers, amino acids and peptitdes, blood buffers. Enzymes; enzymes as biological catalyst, enzyme kinetics, reaction order, methods of plotting enzyme kinetics data, enzyme inhibition, effect of pH on enzyme stability and activity, effect of temperature on enzyme stability and activity, enzyme assays, multisubstrate enzymes and kinetic mechanisms, multisite and allosteric enzymes, enzyme turnover. | ||
| Weekly Course Content | ||
| Week | Subject | Learning Activities and Teaching Methods |
| 1 | Chemical reaction, reaction rate, effect of concentration on reaction rates, order of reaction, the rate constant of the reaction | slide show |
| 2 | One-step irreversible reaction, One-step reversible reaction, Irreversible binding reaction, Reversible binding reaction | slide show |
| 3 | Two-step irreversible reaction Two-step reversible reaction Two-step reversible binding reaction: induced fit Two-step reversible binding reaction: conformational selection | slide show |
| 4 | Mechanism of Enzyme Catalyzed Reactions | slide show |
| 5 | Enzyme catalysis with a single substrate, Enzyme catalysis with two substrates, Identification of the rate-limiting step | slide show |
| 6 | Enzyme catalysis with a single substrate, Enzyme catalysis with two substrates, Identification of the rate-limiting step | slide show |
| 7 | Graphical Determination of Kinetic Constants | slide show |
| 8 | mid-term exam | |
| 9 | Enzyme inhibition, | slide show |
| 10 | Regulation of Enzyme Activity | slide show |
| 11 | Effect of pH and temperature on enzyme stability and activity, | slide show |
| 12 | Multisite and allosteric enzymes, enzyme turnover | slide show |
| 13 | Protein Folding | slide show |
| 14 | Membrane Transporters, pumps and channels | slide show |
| 15 | Polymerization reactions | slide show |
| 16 | final exam | |
| Recommend Course Book / Supplementary Book/Reading | ||
| 1 | Enzyme Kinetics: A Modern Approach, Wiley-Interscience; 1 edition (November 15, 2002) | |
| Required Course instruments and materials | ||
| Projector | ||
| Assessment Methods | |||
| Type of Assessment | Week | Hours | Weight(%) |
| mid-term exam | 8 | 40 | |
| Other assessment methods | |||
| 1.Oral Examination | |||
| 2.Quiz | |||
| 3.Laboratory exam | |||
| 4.Presentation | |||
| 5.Report | |||
| 6.Workshop | |||
| 7.Performance Project | |||
| 8.Term Paper | |||
| 9.Project | |||
| final exam | 16 | 60 | |
| Student Work Load | |||
| Type of Work | Weekly Hours | Number of Weeks | Work Load |
| Weekly Course Hours (Theoretical+Practice) | 3 | 14 | 42 |
| Outside Class | |||
| a) Reading | 3 | 14 | 42 |
| b) Search in internet/Library | 5 | 14 | 70 |
| c) Performance Project | 0 | ||
| d) Prepare a workshop/Presentation/Report | 0 | ||
| e) Term paper/Project | 0 | ||
| Oral Examination | 0 | ||
| Quiz | 0 | ||
| Laboratory exam | 0 | ||
| Own study for mid-term exam | 10 | 1 | 10 |
| mid-term exam | 1 | 1 | 1 |
| Own study for final exam | 7 | 2 | 14 |
| final exam | 1 | 1 | 1 |
| 0 | |||
| 0 | |||
| Total work load; | 180 | ||