Information Of Programmes

INSTITUTE OF SCIENCE / MBG508 - MONECULER BIOLOGY AND GENETICS

Code: MBG508

Course Title: ADVANCED IMMUNOLOGY

Theoretical+Practice: 3+0

ECTS: 6

Year/Semester of Study

1 / Spring Semester

Level of Course

2nd Cycle Degree Programme

Type of Course

Optional

Department

MONECULER BIOLOGY AND GENETICS

Pre-requisities and Co-requisites

None

Mode of Delivery

Face to Face

Teaching Period

14 Weeks

Name of Lecturer

MUSA KAR (musa.kar@nevsehir.edu.tr)

Name of Lecturer(s)

Language of Instruction

Turkish

Work Placement(s)

None

Objectives of the Course

To lead students to gain below outcomes; 1: will have information about the tissues and cells of the immune system, 2: know mechanisms of the innate and adaptive immunity, 3: have knowledge about integration of the cellular and humoral immunities against pathogens that invade our organisms, molecular bases of the antigen processing and antigen presentation to the immune system. 4: This basic knowledge will allow students to better understand topics such as diseases of the immune system, transplantation, allergy and tumor immunology.

Learning Outcomes		PO	MME
The students who succeeded in this course:
LO-1	Define cells and tissues of the immune system and effector mechanisms of innate and adaptive immuniies	PO-	Examination
LO-2	Distinguish differential processing of intracellular and extracellular antigens and their activation of distinct subsets of T cells by MHC class I and MHC class II molecules.	PO-	Examination
LO-3	Explain development of T and B cells and the mechanisms of cellular and humoral immunities.	PO-	Examination
PO: Programme Outcomes MME:Method of measurement & Evaluation

Course Contents
Definitions of immunology, definitions of acquired and adaptive immunity and differential differences, immune system cell types, antibody-antigen functions, processing of antigens and submission to defense cells, autoimmune disorders
Weekly Course Content
Week	Subject	Learning Activities and Teaching Methods
1	Basic concepts in immunology. The bases of innate and adaptive immunity.	Discussion Method, Narrative Method
2	Cells and tissues of the immune system	Discussion Method, Narrative Method
3	Circulation of cells of the immune system and theri migration into tissues	Discussion Method, Narrative Method
4	Innate immunity: cellular abd soluble sensors and effector molecules. Inflammation and anti-viral response. Complement system	Discussion Method, Narrative Method
5	Antigens and antibodies. Structure-function relationship of antibodies. The chemistry of antigen-antibody binding.	Discussion Method, Narrative Method
6	Antigen processing in MHC Class I and II pathways. Functions of MHC Complex. Prsentation of antigens to T cells.	Discussion Method, Narrative Method
7	Signaling through immune system and cytokine receptors	Discussion Method, Narrative Method
8	mid-term exam
9	Development of B and T lymphocytes. Mechanisms of rearrangement of antigen receptors.	Discussion Method, Narrative Method
10	Activation of T cells. Activating signals and functional responses.	Discussion Method, Narrative Method
11	Differentiation and functions of CD4 and CD8 T cells. Properties of effector T cells. T Cell-dependent cytotoxicity.	Discussion Method, Narrative Method
12	Activation of B cells and antibody production.	Discussion Method, Narrative Method
13	Humaral immune responses. Functions of antibody isotypes	Discussion Method, Narrative Method
14	Structure of mucosal immune system.and mucosal immune responses against pathogens.	Discussion Method, Narrative Method
15	General Assessment	Discussion Method, Narrative Method
16	final exam
Recommend Course Book / Supplementary Book/Reading
1	Abul K. Abbas, Andrew H. Lichtman, & Shiv Pillai. Cellular and Molecular Immunology, 9. baskı, Elsevier (2018) ISBN: 978-0-323-52324-
Required Course instruments and materials

Assessment Methods
Type of Assessment	Week	Hours	Weight(%)
mid-term exam	8	2	40
Other assessment methods
1.Oral Examination
2.Quiz
3.Laboratory exam
4.Presentation
5.Report
6.Workshop
7.Performance Project
8.Term Paper
9.Project
final exam	16	2	60

Student Work Load
Type of Work	Weekly Hours	Number of Weeks	Work Load
Weekly Course Hours (Theoretical+Practice)	3	14	42
Outside Class
a) Reading	3	14	42
b) Search in internet/Library	3	10	30
c) Performance Project			0
d) Prepare a workshop/Presentation/Report	2	1	2
e) Term paper/Project			0
Oral Examination			0
Quiz			0
Laboratory exam			0
Own study for mid-term exam	3	10	30
mid-term exam	2	1	2
Own study for final exam	3	10	30
final exam	2	1	2
			0
			0
Total work load;			180