Nevşehir Hacı Bektaş Veli University Course Catalogue
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| Year/Semester of Study | 1 / Fall Semester | ||||
| Level of Course | 3rd Cycle Degree Programme | ||||
| Type of Course | Optional | ||||
| Department | TEKLİF EDİLEN KIMYA (DOKTORA) | ||||
| Pre-requisities and Co-requisites | None | ||||
| Mode of Delivery | Face to Face | ||||
| Teaching Period | 14 Weeks | ||||
| Name of Lecturer | CEVAHİR ALTINKAYNAK (caltinkaynak@nevsehir.edu.tr) | ||||
| Name of Lecturer(s) | CEVAHİR ALTINKAYNAK, | ||||
| Language of Instruction | Turkish | ||||
| Work Placement(s) | None | ||||
| Objectives of the Course | |||||
| The aim of this course is to give information about mechanisms of in vitro and in vivo protein folding and spectroscopic techniques used in folding and stability studies. | |||||
| Learning Outcomes | PO | MME | |
| The students who succeeded in this course: | |||
| LO-1 | Can read and understand publications on protein folding. |
PO-2 Can make connections between different disciplines and sub-fields that their field is related to by using their expert knowledge and skills, work in harmony in research groups. PO-3 Can closely follow national and international developments in the field of chemistry. PO-5 Can have the ability to search literature, make presentations, design and prepare experimental setups, and interpret the relevant results. |
Examination Presentation Term Paper |
| LO-2 | Can comprehend the effects of protein misfolding. |
PO-9 Can produce solutions to social, scientific, and ethical issues by combining their own knowledge and perspective with up-to-date information about their field. PO-13 can defend their original views with experts in the discussion of issues in their field at international platforms and can communicate effectively, showing their competence in the field PO-14 Able to communicate at an advanced level in written and oral communication in at least one foreign language. |
Examination Presentation Term Paper |
| LO-3 | Can comprehend the importance of the relationship between protein structure and function. |
PO-7 Can develop new ideas and methods with different perspectives by using high-level competencies such as suggesting solutions to problems that arise in the field and making decisions. PO-8 Can design theoretical, experimental, or modeling-based research that will contribute to progress in the field, develop new scientific methods, and apply a known method to a different field. PO-9 Can produce solutions to social, scientific, and ethical issues by combining their own knowledge and perspective with up-to-date information about their field. |
Examination Presentation Term Paper |
| LO-4 | Can explain the basic concepts about the kinetic and thermodynamic mechanisms of protein folding. |
PO-6 Can has a scientific and professional ethical understanding and can defend this understanding in any environment. PO-7 Can develop new ideas and methods with different perspectives by using high-level competencies such as suggesting solutions to problems that arise in the field and making decisions. PO-8 Can design theoretical, experimental, or modeling-based research that will contribute to progress in the field, develop new scientific methods, and apply a known method to a different field. |
Examination Presentation Term Paper |
| LO-5 | Can follow the current developments regarding protein folding and stability. |
PO-3 Can closely follow national and international developments in the field of chemistry. PO-4 Can systematically follow up-to-date information in the field. PO-5 Can have the ability to search literature, make presentations, design and prepare experimental setups, and interpret the relevant results. |
Examination Presentation Term Paper |
| PO: Programme Outcomes MME:Method of measurement & Evaluation |
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| Course Contents | ||
| The content of the course consists of factors affecting protein folding, in vivo protein folding, proteins that help folding, membrane protein folding, diseases caused by protein misfolding, spectroscopic techniques in the examination of protein folding and stability, denaturation of proteins with urea and guanidine hydrochloride, and thermal denaturation. | ||
| Weekly Course Content | ||
| Week | Subject | Learning Activities and Teaching Methods |
| 1 | Secondary and tertiary structure of proteins, importance of protein folding and stability studies. | Explaining method, question and answer teaching method |
| 2 | Factors affecting protein folding and stability | Explaining method, question and answer teaching method |
| 3 | Protein folding problem and Levinthal’s paradox | Explaining method, question and answer teaching method |
| 4 | Mechanisms of protein folding | Explaining method, question and answer teaching method |
| 5 | Spectroscopic Techniques to Study Protein Folding | Explaining method, question and answer teaching method |
| 6 | Denaturation of proteins by urea and guanidine hydrochloride. | Explaining method, question and answer teaching method |
| 7 | Protein folding in vivo. Chaperon proteins | Explaining method, question and answer teaching method |
| 8 | mid-term exam | |
| 9 | Folding of membrane proteins | Explaining method, question and answer teaching method |
| 10 | Protein misfolding | Explaining method, question and answer teaching method |
| 11 | Project Presentation | Discussion and project presentation |
| 12 | Project Presentation | Discussion and project presentation |
| 13 | Project Presentation | Discussion and project presentation |
| 14 | Project Presentation | Discussion and project presentation |
| 15 | Project Presentation | Discussion and project presentation |
| 16 | final exam | |
| Recommend Course Book / Supplementary Book/Reading | ||
| 1 | Telefoncu, A. (2009). Protein Analitiği, Ege Üniversitesi. | |
| 2 | Telefoncu, A. (2007). Protein Mühendisliği, Ege Üniversitesi. | |
| Required Course instruments and materials | ||
| Assessment Methods | |||
| Type of Assessment | Week | Hours | Weight(%) |
| mid-term exam | 8 | 2 | 30 |
| Other assessment methods | |||
| 1.Oral Examination | |||
| 2.Quiz | |||
| 3.Laboratory exam | |||
| 4.Presentation | 15 | 1 | 20 |
| 5.Report | |||
| 6.Workshop | |||
| 7.Performance Project | |||
| 8.Term Paper | 11 | 2 | 20 |
| 9.Project | |||
| final exam | 16 | 2 | 30 |
| Student Work Load | |||
| Type of Work | Weekly Hours | Number of Weeks | Work Load |
| Weekly Course Hours (Theoretical+Practice) | 3 | 14 | 42 |
| Outside Class | |||
| a) Reading | 4 | 8 | 32 |
| b) Search in internet/Library | 4 | 8 | 32 |
| c) Performance Project | 0 | ||
| d) Prepare a workshop/Presentation/Report | 3 | 6 | 18 |
| e) Term paper/Project | 3 | 6 | 18 |
| Oral Examination | 0 | ||
| Quiz | 0 | ||
| Laboratory exam | 0 | ||
| Own study for mid-term exam | 2 | 4 | 8 |
| mid-term exam | 7 | 1 | 7 |
| Own study for final exam | 4 | 4 | 16 |
| final exam | 7 | 1 | 7 |
| 0 | |||
| 0 | |||
| Total work load; | 180 | ||